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(2019) performed a randomized controlled trial involving 56 women with PCOS, revealing a decrease in hirsutism, total testosterone, hs-CRP, and MDA, alongside an increase in TAC and total GSH among participants administered 5 g of melatonin twice daily for 12 weeks, in contrast to the placebo group [186]

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However, the regulatory mechanisms of Ca 2+ mobilization by metformin remain obscure, and further investigations are required to confirm the causal relationship with LKB1